GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | LY6D | chr8:143866298-143868008:- | 0.23 | 5.01 | 8.22E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | PSCA | chr8:143761875-143764142:+ | 0.5 | 15.29 | 1.58E-41 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs1045605 | chr8:143764101 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.81 | 2.19E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs1045605 | chr8:143764101 | PSCA | chr8:143761875-143764142:+ | 0.52 | 16.1 | 6.31E-45 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs9473555 | 1 | rs10456622 | chr6:49396453 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.48 | 7.91E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs10456622 | chr6:49396453 | MUT | chr6:49398994-49431031:- | 0.29 | 5.73 | 2.05E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs10461617 | 1 | rs10461617 | chr5:56104308 | C5orf35 | chr5:56205103-56213010:+ | 0.71 | 10.51 | 7.18E-23 | Type 2 diabetes |
| BLCA | cis | rs7714584 | 1 | rs10463240 | chr5:150256853 | LOC134466 | chr5:150310000-150326146:- | 0.48 | 6.27 | 9.54E-10 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10463307 | chr5:150254620 | LOC134466 | chr5:150310000-150326146:- | 0.53 | 6.71 | 6.95E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs10463310 | chr5:150260905 | LOC134466 | chr5:150310000-150326146:- | 0.47 | 6.2 | 1.42E-9 | Crohn's disease |
| BLCA | cis | rs9876781 | 1 | rs10470686 | chr3:48449956 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.86 | 0.000132 | Longevity |
| BLCA | cis | rs3743832 | 1 | rs1048687 | chr16:9212987 | C16orf72 | chr16:9185537-9213545:+ | -0.23 | -3.91 | 0.000107 | Behavioural disinhibition (generation interaction);Non-substance related behavioral disinhibition |
| BLCA | cis | rs6684514 | 1 | rs10494304 | chr1:156285764 | BGLAP | chr1:156182784-156213112:+ | -0.22 | -3.86 | 0.000135 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| BLCA | cis | rs9309473 | 1 | rs10496191 | chr2:73673798 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.82 | 1.23E-8 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs10496193 | chr2:73773503 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.79 | 1.49E-8 | Metabolite levels |